Practical and economic lithiations of functionalized arenes and heteroarenes using Cy2NLi in the presence of Mg, Zn or La halides in a continuous flow.
نویسندگان
چکیده
The economic amide base lithium dicyclohexylamide (Cy2NLi) allows fast and convenient (40 s, 0 °C) in situ trapping flow metalations of a broad range of functionalized arenes, heteroarenes and acrylate derivatives in the presence of various metal salts (ZnCl2·2LiCl, MgCl2, LaCl3·2LiCl). The resulting Zn-, Mg- or La-organometallic intermediates are trapped with various electrophiles in high yields. These flow metalations are easily scaled-up without further optimization.
منابع مشابه
Practical and economic lithiations of functionalized arenes and heteroarenes using Cy2NLi in the presence of Mg, Zn or La halides in a continuous flow† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc02558c ‡ ‡We thank the SFB 749 (DFG) for support and financial contributions to this project. We also thank Rockwood Lithium GmbH (Frankfurt) and BASF AG (Ludwigshafen) for the generous gift of chemicals.
The economic amide base lithium dicyclohexylamide (Cy2NLi) allows fast and convenient (40 s, 0 C) in situ trapping flowmetalations of a broad range of functionalized arenes, heteroarenes and acrylate derivatives in the presence of various metal salts (ZnCl2$2LiCl, MgCl2, LaCl3$2LiCl). The resulting Zn-, Mgor Laorganometallic intermediates are trapped with various electrophiles in high yields. T...
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ورودعنوان ژورنال:
- Chemical science
دوره 6 11 شماره
صفحات -
تاریخ انتشار 2015